This work was performed during the two consecutive winter seasons of 2015/2016 and 2016/2017 at the Farm of the Faculty of Agriculture, Assiut University (New Valley Branch), to investigate the effect of foliar spray with bio-stimulant namely yeast extract (0, 1, 2 and 3 %), and two antioxidants; i.e., salicylic acid and ascorbic acid at 200 ppm of each, beside control treatment on plant growth, yield and its components as well as bulb quality of garlic cv. Sids-40 under newly reclaimed soil of New Valley-Egypt. Results showed that the interaction between foliar spray with yeast extract at 3 % and sprayed plants with salicylic acid at 200 ppm was the best interaction treatment for increasing plant growth traits, i.e., plant height, leaf area/plant both fresh and dry weight/plant, bulbing ratio, mineral contents (N, P, K and S in leaves and bulb) and biochemical concentration in leaves (total carbohydrates and salicylic acid) after 135 days from planting time, total yield/fed. and bulb parameters as well as bulb quality (total carbohydrates and salicylic acid contents) at harvesting time, while the interaction between yeast extract at 3 % and sprayed plants with ascorbic acid at 200 ppm gave the highest values of ascorbic acid content in leaves and bulb at 135 days after planting and harvesting time respectively in both seasons. The increases in total yield were about 166.9 and 165.1 % for the interaction treatment between the plants which sprayed with yeast extract at 3 % and salicylic acid at 200 ppm; 148.9 and 151.3 % for the interaction treatment between the same rate of yeast extract and sprayed plants with ascorbic acid at 200 ppm over control treatment in the 1^st and 2^nd seasons, respectively.