The field experiment was carried out during two successive summer seasons of 2014 and 2015 at the agricultural experimental station of Khamisa, Desert Research Center Siwa Oasis, to study the response of three sunflower varieties, i.e. Hysun333, Sakha 53 and Giza 102 to foliar application by natural compounds chitoker. Seven natural compound treatments which used were , 1- without natural compound (as control), 2-spraying by 150 ml./100 liters in the vegetative growth stage, 3- spraying by 150 ml./100 liters in the vegetative and syphilis  growth stages. 4- Spraying by 200 ml./100 liters in the vegetative growth stage, 5- spraying by 200 ml./100 liters in the vegetative. 6- Spraying by 250 ml./100 liters twice in the vegetative   growth stage, and, 7- spraying by 250 ml./100 liters twice in the vegetative and syphilis growth stages.The obtained results could be summarized as follows:Sunflower verities were differed significantly in yield and its components, oil contents and oil yield. Giza 102 variety was superior to Hay Sun 333 and Sakha 53 varieties.A significant difference between the parameters of the natural compounds as chitoker, where the spraying twice by chitoker  at 250 ml./100 liters of during the vegetable and flowering stages had a significant increase as compared to the rest of the treatments. All studied traits were significantly affected by the interaction between varieties and spraying by different chitoker treatments. An general, sprayed Giza 102 variety twice by the natural Chitoker at 250 ml. / 100 L. rate during vegetative and pre- flowering stages produced the highest yield, yield components and oil yield.The results of the calculation of the economic yield of the crop showed that the cultivation of the sunflower crop in Giza 102 + spraying with the natural compound Chitoker rate of 250 ml./100 liters of water in two stages are spraying in the stage of vegetable growth and spray in pre-growth flowering Is the best experimental economic transaction for the farmer, With some other factors being given an economic rate but to a lesser degree. This study concluded that the cultivation of  Giza 102 sunflower variety + spraying  twice  with the natural compound Chitoker rate of 250 ml./100 liters of water in two stages of vegetable  and pre-growth of the Zahra under the conditions of Siwa Oasis gave the best results economically.