In order to study the effect of fertilization systems (100 % NPK, 100 % compost, 50 % compost + 500 kg mineral ores mixture and 50 % compost + 500 kg gypsum) as soil application and organic substances (control, KP, KSi and CT) as foliar application on growth performance, chlorophyll content, nodulation and yield of peanut (Arachis hypogaea L., Giza 6 cv.). Two   field experiments were carried out in extension field at Quweisna, Menoufia governorate, Egypt during the two growing seasons of 2015 and 2016. Results indicated that adding fertilization systems and organic substances generally had effective roles on enhancement of growth and yield of peanut grown in sandy loam soil. Application of 50 % compost + mineral ores mixture produced the highest   growth  characters i.e  number of main branches and leaves /plant, stem and leaves dry weight/plant and leaf area/plant . However, application of 100 % compost exhibited more total chlorophyll content, number and nodules weight/plant, yield and its components (number of pods/ plant, number of seeds / pod, weight of seed /plant and pod yield per plant and per fed and seed oil percentage compared with other tested fertilization treatments. The response of peanut Chlorophyll and nodulation, yield and oil percentage significantly differed by foliar application of organic substances. Application of Jeta Plus (KP) and Si-ElGhanem (KSi ) surpassed the other organic substances for producing highest values of most above mentioned characteristics. However, untreated plants recorded the lowest values of all studied characteristics. The interactions between the fertilization systems and organic substances were found to be significant for most studied traits. The maximum pod yield/fed was obtained by soil application of 100 % compost combined with foliar application with KP, which is found to be the best combination for maximizing peanut productivity. Accordingly, the study recommends the importance of regular use of organic fertilization as soil or foliar application to reduce the need for synthetic commercial fertilizers and reduced soil pollutions.