The present work was conducted at the Experimental Station Farm, Faculty of Agriculture, Mansoura University, Egypt, during the two successive winter (critucal) cultivation of 2015/2016 and 2016/2017 to investigate the impact of irrigation water (normal water - magnetized water), levels of soil mineral fertilizers and foliar spraying with nano-material (without - Lithovit) as well as their interactions on growth, yield, chemical composition and quality of potato cv. Spunta. Obtained data cleared that irrigation with magnetized water produced the highest significant values of plant growth, chlorophylls, yield, chemical composition and quality parameters except nitrate (NO₃) and nitrite (NO₂) contents compared to normal water treatments. Meanwhile, fertilized potato plants with 100% NPK from recommended dose gave the maximum values of all studied parameters, except nitrate (NO₃) and nitrite (NO₂) concentrations which increased compared to other treatments. Moreover, foliar spraying with Lithovit as a nono material increased significantly all studied characters, except nitrate and nitrite, which gave the lowest values in both seasons. It could be recommended that irrigation potato plants with magnetized water, 50% NPK from the recommended dose and foliar spraying with Lithovit (1g/L) in order to maximize productivity, quality parameters and limiting the environmental pollution comparing to plant irrigated with normal water + 100% NPK.