Two field experiments were conducted at Private Farm Al-Doaa region, Baltim, Kafr Ash Shaykh, Egypt in 2015, 2016 seasons to study the effect of some osmo-regulators and/or antioxidants to ameliorate the harmful effects of salinity stress on Top Star hybrid sweet pepper (Capsicum annuum, L) plants in sandy soil under drip irrigation system, during the early summer season on vegetative growth, fruit yield and quality.The obtained results could be summarized as follows:Soil application of Kitasal (2 ml/l) gave the longest plant, heaviest fresh and dry weight, largest leaf area, and gave the highest fruit yield (ton/fed.) compared with other treatments in both seasons. All foliar applications significantly increased all studied parameters compared with the untreated plants. The superior application was 250 ppm glycine-betaine followed by Glutathione (50 ppm) or Potassium silicate (250 ppm) in both seasons, respectively. Interaction between soil application of Kitasal (2 ml/l) and foliar application of glycine-betaine (250 ppm) gave the highest values of vegetative growth represented by plant height, leaf area fresh and dry weight along with, fruit yield and its component represented by fruit weight, yield/plant, and total yield/fed. From the obtained results it could be concluded that, using Kitasal (2ml/l) as soil application in combination with foliar application of 250 ppm glycine-betaine improved both growth and yield of sweet pepper plants under salinity condition.