Two field experiments were conducted at Rice Research and TrainingCenter, Sakha, Kafr El-Sheikh, Egypt during 2015 and 2016 seasons to detect the effect of water regime and weed control treatments on weeds, growth and yields of hybrid rice (Sk2034H). Water regime (4-days on and 6-days off, saturation and continuous flooding) were allocated in main plots while weed control treatments were Thiobencarb 50% EC at three rates; 1.8 , 2.4 and 3.6 kg ai ha^{-1 in addition to weedy check were distributed in sub-plots. Weed species and hybrid rice yields were greatly influenced by water regime and weed control treatments. Echinochloa crus-galli and total weeds dry weights were significantly reduced under flooded or saturated plots than under shortage of water (4-days on + 6-days off). In different response, Cyperus difformis considerably reduced under the water shortage than saturated or flooded plots. The highest values of panicles per hill} and grain yield of hybrid rice were recorded under flooding conditions followed by saturated soil. The application of  Thiobencarb 50% EC at the high rate (3.6 kg ai h^-1) resulted in the best weed control and highest grain yield followed by the application of 2.4 kg ai ha^-1 from the same compound, while weedy check plots recorded the highest in weed presence and the lowest in rice yields. For the interaction, the lowest dry weights of Echinochloa crus-galli, Cyperus difformis and total weeds, also the largest weed control efficiency (%), number of panicles per hill and the highest rice grain yields were obtained under flooded plots treated with Thiobencarb at both rates of 2.4 and 3.6 kg ai ha^-1. This trend was true under all treatments even the weedy check plots except for Cyperus difformis which increased significantly by soil saturation or flooding in un-treated plots.