This investigation was carried out during two successive seasons of 2014 and 2015 on mature pomegranate trees cv. Manfalouty grown in calcareous soil at Borg-El-Arab region, Alexandria governorate, Egypt. It was conducted to determine if a combination of fast or slow release (i e phosphorus coated urea PCU 37%) nitrogen fertilizer with different levels of soil moisture can enhance growth of Manfalouty pomegranate trees with high productivity as compared to the current production practices as well as to reduce both rate and number of soil applications during the growing season. The results showed that all vegetative growth, leaf mineral contents and fruit characteristics parameters were significantly affected by interaction between levels of soil moisture of field capacity (FC) and slow-release nitrogen fertilizer. The chemical fruit characteristics, i e TSS, TSS/ acidity, vitamin C and anthocyanin were the maximum  values at 50% FC + 400 g actual slow release nitrogen fertilizer, while the acidity value was the highest in the treatment of 100% FC + 200 g/tree as a slow release nitrogen fertilizer in both seasons. The fruit set was the maximum at 75% FC +200 or 300 g actual slow release nitrogen fertilizer in the first and second seasons, respectively. Also, yield showed the highest significant values of 44.1 and 47.1 Kg/tree with the treatment of 100% FC+ 400 g/tree in the first and second seasons, respectively. Moreover, the results showed that the combination between the 100% FC irrigation treatment and the highest amount of slow release fertilizer of 400 g actual slow release nitrogen fertilizer /tree produced the highest values of most vegetative growth traits i.e., tree height, shoot length, dry weight of 30 leaves, and chlorophyll content (SPAD) in both seasons. Also leaf nitrogen, potassium, phosphorus and magnesium content was increased under such conditions.