One experiment was conducted in 2014 and respected in 2015 rice seasons at the farm of RiceResearch & TrainingCenter, Sakha, Kafrelsheikh, Egypt. To study the impact of different time and method of potassium and various levels of Cytokinin and their interaction on the yield and its components, some grain quality characters and uptake of N, P and K. The treatments of potassium were (1) control ( Zero potassium) (K1), (2) Full dose as basal (B) (K2), (3) Half dose of potassium as basal + 2% K₂O spray at mid-tillering and late booting (K3), (4) Half dose of potassium as basal + 2% K₂O spray at mid tillering (K4), (5) Half dose of potassium as basal + 2% K₂O spray at late booting (K5) and (6) 2% K₂O spray at mid-tillering and late booting (K6). Cytokinin (Kinetin) treatments were Control (water spray) (C1), 5 ppm (C2), 10 ppm (C3), 15ppm (C4) each of them sprayed at both mid tillering and late booting. The design of the experiment was split plot with four replications. The main plots had the potassium treatments, while sub plots received the Cytokinin treatments. The studied characters were number of panicles/m², weight of panicle, number of grains/panicle, filled grain %, 1000-grain weight, grain and straw yield, Some of grain quality characters and the uptake of nitrogen, phosphorus and potassium. The main results indicated that all the studied treatments of both potassium and Cytokinin caused an increase in all studied characters as compared with control. The best treatments of potassium was half of the dose of potassium + 2% K2O sprayed at mid + 2% K2O sprayed at L.B which caused a significant increase in all the previous studied characters because of its continuous supply the tested cultivar by K through the different stages. Also, sprayed Cytokinin at the rate of 15 ppm at both mid tillering and late booting significantly increased all the studied characters because of the role of cytokinin for improving the growth of roots and shoots as well as the increasing in viability of rice leaves (late senescence of leaves). As for the interaction between potassium (K) treatments and Cytokinin levels, the results revealed that the combination of half dose of potassium + 2% K2O sprayed at both mid tillering and late booting with 15 ppm sprayed at mid tillering and late booting produced the greatest values in all the studied characters.