Filed experiment was conducted during winter seasons (2014-2015, 2015-2016 and 2016-2017) to study the effect of organo-mineral fertilization (NPK, compost , poultry manure, ½ NPK 16 ">  + compost and ½ NPK + poultry manure) on vegetative growth and production  of two potato cultivars (Rosetta and Burren) under EL-Dakhala Oasis (latitude 25 35 2.35N , longitude 29 0 31.62 E) New valley governorate . The amount of the used fertilizers was 300 kg Ammonium nitrate 33.5% (NH₄ NO₃). In addition, Super phosphate (15.5% P₂O₅) was applied at rate of 387 kg/fed and potassium sulfate (50 % K₂O) was added at rate of 200 kg/fed. The compost was added as 11 tons / fed and the poultry manure was added at rate of 4 tons/fed. Half of the above amounts of mineral fertilizers, NPK, were added when either of the organic materials were mixed with NPK. The experiment was laid out in randomized complete block design using split plot arrangement with four replications. The two potato cultivars were arranged in the main plots while, the five organo-minerals treatments were allocated in the sub plots. The results showed that all studied factors and their interaction had a significant effect on the studied traits. Burren potato cultivar surpassed Rosetta cultivar in all studied traits. Moreover, organo-mineral fertilization (½ NPK + compost fertilizer) was superior treatment in all studied traits followed by ½ NPK + poultry manure compared to NPK or organic manures alone. Furthermore, the highest mean values of the studied traits were obtained by Burren cultivar that fertilized with ½ NPK + compost and ½ NPK + poultry manure under New valley conditions.