Two field experiments were conducted to study the effect of foliar and NPK fertilization on productivity and grains quality of wheat Misr 1 cultivar during 2014/2015 and 2015/2016 seasons at a private field in Dekernis Center, Dakahlia Governorate, Egypt. The experiments were carried out in a strip-plot design with four replicates. The vertical plots were assigned to six foliar treatments i.e. without, spraying with; commercial NPK as Ferti-plus powder (20-20-20), solution of micro-elements (Zn, Mn and Fe), amino acids in the form of Amino-Cat, yeast extract (YE) and the mixture of commercial NPK, micro-elements, amino acids and yeast extract. The horizontal plots were allocated to three levels of NPK fertilizers (60, 80 and 100 % of the recommended doses i.e. 80 kg N + 45.0 kg P₂O₅ + 48.0 K₂O/fed). The foliar spraying twice with the combination of commercial NPK, -elements, amino acids and yeast extract produced the highest values of  all studied characters in both seasons, Followed by foliar spraying wheat plants twice with yeast extract (YE) (100 ml/Liter water) in each spraying. Fertilizing with 80 + 45.0 + 48.0 kg N, P₂O₅ and K₂O/fed gave the maximum values of all studied characters during both seasons. Mineral fertilizing with 64.0 + 36.0 + 38.4 kg N, P₂O₅ and K₂O/fed/fed ranked secondly after the highest level of NPK fertilization. It can be accomplished that foliar spraying wheat Misr 1 cultivar twice with the combination of commercial NPK, micro-elements, amino acids and yeast extract beside mineral fertilizing with 64.0 + 36.0 + 38.4 kg N, P₂O₅ and K₂O/fed/fed under the environmental conditions of Dekernis Center, Dakahlia Governorate, Egypt in order to maintain high productivity and grains quality at the same time reduce production costs and environmental pollution.