In order to study the enhancement of sunflower production under sandy soil of Toshka region. The present study was undertaken during 2017 and 2018 seasons to examine the impact of using four nitrogen sources (N) i.e., N₁=45 kg N/fed as a mineral form (min), N₂=45 kg N/fed as organic form (org.), N₃=30 kg N/fed min.+15 kg N/fed org., N₄=15 kg N/fed min.+30 kg N/fed org., and four foliar spraying with antioxidants (A) i.e., A₁= without spraying, A₂=200ppm salicylic acid (SA), A₃=3g/L yeast extract (YE) and A₄=200ppm ascorbic acid (AA) as well as their interaction on the vegetative growth, yield and its quality as well as economics return of sunflower cv. Sakha-53. The obtained results indicated that application of nitrogen sources and antioxidants foliar spraying  had significant influence on No. of leaves/plant, leaf area/plant, stem diameter, total chlorophyll, flowering date, plant height, head diameter, 100-seed weight, seed and oil yield as well as oil and protein percentage in both seasons. The results recorded fertilizing with 30 kg N/fed min.+15 kg N/fed org. (N₃) increased seed yield (ton/fed) by 5.95 and 9.20 % in 1^st and 2^nd seasons, respectively compared to the N₂ treatment. Spraying with yeast extract at 3 g/L (YE) gave the highest values of seed and oil yield in both seasons when compared with salicylic acid and ascorbic acid treatments. The interaction significantly affected seed yield and some of its traits. The highest seed yield (1.90 and 1.91 ton/fed) was recorded for 30 kg N/fed min.+15 kg N/fed org. and foliar spraying with yeast extract in 1^st and 2^nd seasons, respectively as well as net return (4409.15 L.E/fed) as an average of the two seasons, but highest economic efficiency was (96 %) resulted from N₁ × A₃. It could be recommended with fertilizing with 30 kg N/fed as mineral+15 kg N/fed as organic fertilizer with foliar spraying yeast extract at 3g/L for maximizing sunflower seed yield and net return under Toshka region.