Enhancing potato growth and yield attributes via both Boron (Br) and Selenium (Se) is a great potential nowadays. Therefore, the present investigation was done to study the effe ct of Boron and Selenium singly or in combination as foliar application on plant growth, yield and quality of two potato cultivars 'Lady Rosetta and Caruso' during both seasons of 2016/2017 and 2017/2018. The experimental layout was split plots system in a randomized complete blocks design with three replications. Cultivars were arranged as the main plots and concentrations of Boron and Selenium singly or in combination were assigned as sub-plots. Boron was sprayed in three concentrations 0, 50, and 100 mg/l whereas Selenium was used at 0, 5, and 10 mg/l concentrations twice at 55 and 70 days after planting. The study indicated that plant growth and yield of potato plants were significantly enhanced by Boron and Selenium treatments. Plant height, tuber dry weight, number of tubers/plant, tuber yield/plant, tuber yield/feddan, tuber TSS %, ascorbic acid, tubers sugars (i.e. starch, reducing, non-reducing and total sugars), leaf total chlorophyll, leaf and tubers contents of N, P, K, Br and Se of both potato cultivars ' Lady Rosetta and Caruso' were significantly enhanced by Boron (100 mg/l) combined with Selenium (5 mg/l) foliar application at 55 and 70 days after planting during both seasons of the study.