Giza 179 Egyptian rice cultivar was grown at Sakha Agricultural  Research Station, Kafr El-Sheikh, Egypt, in 2014 and 2015 seasons; to study the influence of Cyanobacteria and Azospirillum as bio-fertilizer, foliar spraying with solution of simulative compounds (ascobein , humic acid  and water) and three nitrogen levels (100%, 75% and 50% of the recommended chemical nitrogen fertilizer,69 kg N fed^-1) on growth, yield attributes, yield and grain quality. The results show a positive effect of chemical N rate, biofertilizer and simulative compounds on crop growth rate (CGR), panicle numbers m^-2, 1000-grain weight, chemical ccompositions into milled grain such as protein and nitrogen content as well as grain and straw yields . Combination of 75% of chemical nitrogen fertilizer along with any biofertilizer or stimulating compounds were statistically at par with any combination containing the recommended nitrogen fertilizer (100% N) in the most of previous characters. Thus, it concluded that the application Cyanobacteria or Azospirillum with ascobien with humic acid as stimulating compounds as well as 75% of the recommended nitrogen dose could be used successfully to achieve optimum grain yield of Giza 179 Egyptian rice cultivar  with saving  25 % of N fertilizer.