This work was carried out during the two consecutive summers of 2016 and 2017 in the Experimental Station Farm, Faculty of Agriculture and Natural Resources, Aswan University, Egypt on a soil sandy textured soil. This work aimed to study the effect of number of drip irrigation periods/week, foliar spray with some plant nutrients "micronutrients and Biostimulant "and with or without mulching on growth, yield and quality of cucumber. Certain physiological and chemical characters plant height, number of leaves per plant,  number of branches per plant, plant dry weight (g), chlorophyll, reducing sugars, acidity, vitamin C, soluble solids (TSS), No. of day to harvest, early yield (ton/fed.), average fruit weight (g), total yield (ton/fed.), and chemical analyses of plants (N, P and K %). The experimental design was a split-split plots system arranged in a randomized complete block design with three replications. Number of drip irrigation periods/week (2 and 3), foliar spray with some plant nutrients i.e. (control "distilled water", Zinc chelated (Zn 14 % EDTA) at 100 mg/l and Iron chelated (Fe 13.0 % EDTA) at 500 mg/l and seaweed extract 1000 mg/l) and polyethylene mulching treatments i.e. without mulching, clear polyethylene mulch + sugar cane straw mulch and black polyethylene mulch + sugar cane straw mulch. The obtained results revealed that 2 drip irrigation periods/week + black polyethylene mulch + sugar cane straw mulch + 1000 mg/l seaweed extract gave the significant effects in most studied characters under study during both seasons.