Nodule-forming rhizobia and specific legume host are forming the mutualistic interactions between them which involve a series of signaling molecules leading to the establishment of a strong and functional symbiosis between the two partners. The success of symbiotic relationships and form nodule are depend on competitive ability and legume host specificity of rhizobia together with the ability of both rhizobia and legumes to release functionally divergent active molecules. The parameters showing the growth and metabolism of Vicia faba in response to cultivation with different Rhizobia and endophytic bacteria were determine. Combination of Rhizobium with different endophytic bacteria had a positive effect on growth parameters, photosynthetic pigments and carbohydrate content in shoot of Vicia faba, at flowering stage.