This study was undertaken during 2013 & 2014 seasons on 12-year-old Manfalouty pomegranate trees (Punica granatum L.) grown in a private orchard situated at Arab-Elawamer region, Abnoub city, Assiut Governorate, Egypt under drip irrigation system and spaced 4 x 4 meters apart. The aim of this investigation was to examine the effect of using filter cake enriched with yeast and/or EM, as a partial alternative to mineral N fertilizers on growth and flowering aspects, tree nutritional status, yield, fruit splitting % and fruit quality of Manfalouty pomegranate trees grown in sandy soil. The obtained results indicated that, fertilizing trees with filter cake at 50 and 100% of N either alone or with EM and/ or yeast each at 0.2% was considerably effective in stimulating all growth aspects, leaf contents of pigments, N, P, K, Mg, Ca, Zn, Fe, Mn and Cu, number of flowers / tree, number of perfect flowers/tree, marketable yield (kg) and both physical and chemical characteristics of the fruits relative to the control. However, number of male flowers/tree, number of splitted fruits/ tree, fruit peel weight and thickness, total acidity % and total soluble tannins were remarkably reduced by using filter cake with/or without yeast and EM application. Hence, for promoting the remarkable yield and fruit quality which leading to get higher profit of Manfalouty pomegranate trees grown under sandy soil along with controlling fruit splitting, it is advised to use filter cake at 100% of the recommended N (300 g/tree /year) enriched with 0.2 %  yeast and EM1 (2 kg from yeast and 2 L/EM/ton filter cake), four times starting from the first week of January at two months interval.