The purpose of this study was to investigate whether Silybum, Spirulina, and Propolis may have a therapeutic impact when compared to the silymarin medication. .The results revealed that,Negative control showed significant lower in weight gain, feed efficiency ratio,serum HDL-c, total protein, albumin, globulin, catalase(CAT),superoxide dismutase (SOD) and Cytochrome P450(CYP450) and significant higher in serum liver enzyme (ALT,AST,ALP, γ GT),total bilirubin ,creatinine, urea ,uric acid,cholesterol,triglycerides,LDL-c, VLDL-c and cholesterol /HDLc, ,LDLc/HDLc and malondialdehyde (MDA) compared to negative control. Administration of Silymarin, Silybum, Spirulina Propolis  and  mixture of them to liver injured rats for both the treated  or preventive group showed a significant decrease in serum liver enzyme (ALT,AST,ALP, γ GT),total bilirubin ,creatinine ,urea ,uric acid, cholesterol, triglycerides, LDL-c, VLDL-c and cholesterol /HDLc, ,LDLc/HDLc and (MDA) and significant increase in weight gain, feed efficiency ratio, HDL-c, total protein, albumin,globulin,CAT,SOD,andCYP450 in compared to positive control.Histopathological examination revealed that consumption of Silymarin, Silybum, Spirulina Propolis can lower pathological changes in injured.It can be recommended that consumption of Silymarin, Silybum, Spirulina Propolis and mixed them could manage treat liver injury rat  by improve liver and renal function, lipids profiles ,antioxidant enzymes and Cytochrome P450.