Effect of soy portion (10% & 20%) on serum lipids, glucose , function of liver and kidney in rats fed high – cholesterol diets (hypercholestrolemic rats ). The body weight gain of rats fed on diets containing hypercholestrolemic rats +soy protein (10 % &20%) were significantly increased than rats fed on standard diets and hypercholestrolemic rats. There were significantly increased in weight of liver and kidney of rats fed on 10% & 20% soy protein. Results indicated that serum  hypercholestrolemic rats + soy protein (10% & 20%) total cholesterol , triglycerides, low-density lipoprotein (LDL),high-density lipoprotein (HDL) and very low-density lipoprotein (vLDL) significantly decreased as compared with hypercholestrolemic rats. Also, results showed a significant increase in high-density lipoprotein (HDL),whereas hypercholestrolemic rats had a significant increase as compared with control. Also, results showed significantly decreased in low-density lipoprotein (LDL) as compared with control. Whereas serum hypercholestrolemic rats +soy protein (10 % &20%) serum glutamate pyruvate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT) significantly decreased as compared with hypercholestrolemic rats and control groups, while had non significant as hypercholestrolemic rats and control. The urea & creatinine level were significant increased in hypercholestrolemic rats + soy protein (10 % &20%) as compared with hypercholestrolemic rats and control. Treatment of hypercholestrolemic rats with 10 % &20% soy protein diet showed an improvement in serum lipid profile, liver function and histopathology           ( liver& kidney). Encouraging people to increase their dietary intake of soy protein specially Atherosclerosis and hypercholesterolemia.