Thirty six rats were used to study the effect of extract of red cabbage against diabetes induced by HFT/HFR diet. Rats were randomly distributed into 6 groups each containing (n=6). The first group kept as normal control fed standard diet only. The other six groups fed on basal diet and HFT/HFR diet and reclassified into positive control,  red cabbage (RC) as powder and extract at levels groups  (2.5% , 5% of the weight of basal diet), ( 250 mg/kg and 500  mg/kg weight of the rat) . Our results showed significant increase in weight gain, food intake and food efficiency ratio in all groups treated with RC as powder and extract groups comparing with (+ve) group, as well as significant reduction in serum glucose, HbA1c, lipid profile   parameters, liver and kidney biomarkers and nitric oxide (NO) levels, moreover significantly increase in insulin, HDL-c, total antioxidant capacity (TAC) and superoxide dismutase (SOD) levels in treated  all groups treated with RC powder at  level 5% and extract 500 mg/kg groups comparing with (+v) group. This study suggests that treatment with red cabbage powder and extract has a beneficial effect against against diabetes and hyperlipidemia.