Number of studies on humans and animals showed lowering effect of rice bran oil (RBO) as well as other vegetable oils in plasma cholesterol levels. The aim of this study was undertaken to compare this effect of two concentrations (1%) and (2%) of Egyptian-RBO active compounds on hypercholesterolaemia in rats. Four groups of six rats were used, the first group was fed on basal diet (control), while the second group was fed on basal diet plus 1% cholesterol. Groups 3 and 4 were fed basal diet +1 % cholesterol + RBO active compounds (1 and 2 % respectively).  Non significant differences were noticed in the mean values of body weights, organs weights and relative organs weights (organ wt/body wt) between different experimental groups. The results obtained showed no significant changes in transaminase (AST & ALT) activities between different treated groups. No significant effect was observed in plasma urea and creatinine or hemoglobin in different treated groups compared to control group. On the other hand total cholesterol and low density lipoprotein cholesterol data showed a significant increase in hypercholesterolemic groups (50 % and 168 %) compared to control group. Supplementation with rice bran active compounds in groups 4 decreased its level compared to cholesterol group 2. The data obtained revealed that triacylglycerol was significantly decreased due to supplementation with rice bran oil of groups 3 (by 27. 64 %) and 4 (by 15.07%) compared to hypercholesterolemia in rats of group 2.