Weaning is an important nutritional milestone with implications for present and future health. Advice on good weaning practice should be a priority and can help avoid several nutritional problems later on. Optimal timing for the introduction of complementary foods will depend on the infant's physiological and developmental status. Small, frequent meals of easily digestible, smooth, semisolid nutrient- and energy-dense complementary foods should initially be offered while gradually increasing variety in both the type and texture of food. Protein and carbohydrate intake should increase with the infant's age while preference should be given to foods rich in micronutrients. Therefore, the nutritional biochemistry of date diet for weaning rats was investigated, in order to design a more effective program for improved child health and nutrition. This was based on gain body weight (GBW), organ weight, blood cell count and their fractions besides the liver and kidney histology. It seems that the combination of date, sweet potatoes, plant protein formula of antioxidants (ACES) in the presence of proposed additives used (AD) is the best complimentary food to be taken beside the prestfeeding. For simple biological evaluation of the data received in the present study, ranking numbers that proposed for WBC, RBC, Liver histology and kidney histology, were collectively calculated to get the net figures of roughly biological assessment. The results that propounding group 6 formula as the best over all profound group 3 as the worst. It is important to recognize in this study that BW evaluation is not the most reasonable way of assessment, hence, in terms of some biological facts such as blood cell profile and organ tissues pictures, the control is not heather one. However advice on good weaning practice should be a priority and can help avoid several nutritional problems later on, such as excessively faddy eating, faltering growth, constipation, iron deficiency anaemia and obesity. The untimely and inappropriate introduction of complementary foods, similar to that of G6, is shown to be risk factors for both under- and over-nutrition with resultant under- or overweight, stunting and micronutrient deficiencies. Optimal timing for the introduction of complementary foods will depend on the infant's physiological and developmental status.