Forty five samples of raw milk obtained from milk shops, vendors and farms, 20 samples of Ras cheese, 30 samples of Yoghurt, 20 samples of Domiati cheese, 10 of Karich and 5 of Morta were collected from the local market of Domiatti governate. They were all analyzed for the incidence of E.coli . Most of these samples were positive for acid and gas formation in Mac Conky broth. 130 isolates from these were further analyzed for the confirmation of the presence of E.coli and 77 of them were found to be positive.