This study aimed to observe antidiabetic and antioxidant activities of Physalis peruviana L. (Solanaceae) fruit juice and pomace in streptozotocin (STZ)-induced diabetic rats. Physalis peruviana L is well- known as a goldenberry or harankash in Egypt, is used to administer diabetes and its problems. Diabetes was induced using STZ (65 mg/kg, b.w). Four days after STZ induction, diabetic rats received daily 5.0 mL/kg/ body weight of P. Peruviana crude fruit juice and P. Peruviana fruit pomace at 10% level mixed with the diet for 35 days. Metformin (0.5 mg/kg, orally) as a reference. The serum urea and creatinine were measured. In addition to CAT, SOD enzymes, and thiobarbituric acid reactive substances (TBARS) were evaluated in pancreas tissue. P. peruviana fruit juice and pomace significantly (P < 0.05) normalized levels of glucose in blood compared to STZ control group. Serum biochemical parameters including lipid profile and antioxidant status were significantly (P < 0.05) restored toward normal levels in P. peruviana fruit juice and pomace -treated rats as compared to STZ control animals. The protective effect was further confirmed by histological improvements in pancreatic cells of the treated diabetic rats. Encouraging nature medication of hyperglycemia and diabetic complications by Physalis peruviana L. fruit juice and pomace.