This study investigates the ant obesity effects of fermented Kefir and germinated cereals mixed with fermented Kefir on high fat diet induced obese rats. 25male rats each weighting 75±3 gram were apportioned to five groups. Group 1 is the negative group. The rest rats were received high saturated fats (34%) in diet for 56 days to become obese rats. Obesity was confirmed by elevation of serum lipid profile and body weight. Group 2 is control +ve group which fed on high fat diet, Kefir group which fed on high fat diet supplemented with kefir at dose of 4ml /rat/day orally, formula 1 group which fed on high fat diet with 20 % of formula 1(wheat, barley, maize and millet mixture powder melt in 200 ml kefir)and  formula 2 group which fed on high fat diet with 20 % of formula 2(wheat, barley, maize and oat mixture powder melt in 200 ml kefir) for four weeks. This study resulted in a marked improvement of nutritional indicator as kefir Formula 1 and 2 group administration could lower nutritional indicators. However, the administration of kefir, formula1 and formula 2 could reduce lipids parameters.Consumption of kefir significantly reduced the serum leptin, glucose, insulin resistance and progesterone levels but increased insulin and testosterone levels while consumption of formula 1 and 2 could lower serum leptin and insulin resistance and elevate progesterone and testosterone levels compared to control (+ve) group .It is concluded that germinated cereals mixed with kefir could manage treat obesity.