The toxic phorbol ester content of Jatropha curcas seeds cultivated in Egypt in raw whole and a kernel seed was ranged between 24.45 and 43.53 mg/kg, respectively. Detoxifications of phorbol esters from Jatropha curcas by physical treatments were studied. Soaking in water removed 46.13 % and 36.18 % phorbol ester in whole and kernel seeds, respectively. While germination and roasting treatments did not affect the phorbol ester level. Detoxification of phorbol ester by some chemical treatments was also studied.  The NaHCO₃ treatments / 121ºC/ 25 min, the treatment (ethanol 90 % /2 h), (ethanol 90 % + NaHCO₃/121 º C / 25 min) treatment,  sodium hydroxide (4 % NaOH) treatment followed by washing with distilled water, the (4 % NaOH) treatment followed by washing with methanol, the (4% NaOH +10% NaOCl) treatment and  the alkali (2%NaOH or 2%Ca (OH)₂) treatment were decreased significantly the phorbol esters content by (38.21 to 90.81 %) and (42.58 to 95.87 %) with non-defatted whole and kernel seeds, respectively, as well as (40.57 to 93.87 %) and (43.69 to 96.44 %) with defatted whole and kernel seeds, respectively. So effects of some physical and chemical treatments were successful detoxification of phorbol esters content.