The purpose of this work is to investigate the protective effect of pomegranate, red beetroot juices or their mixture on the brain toxicity induced by AlCl₃ in rats. Five groups (7 rats each) were used in the experiment; one of them continued feeding on basal diet only during the period of experiment (normal control). Another group was injected daily by AlCl₃ beginning from the 14^th day and served as positive control while the remaining three groups were treated by pomegranate, red beetroot and their mixture juices from the first day till the end of the experiment and from the 14^th day, they were injected by AlCl₃ until the end of the experiment. Phenolic compounds, flavonoids, vitamin C and DPPH scavenging activity of pomegranate and red beetroot juices were estimated. The results revealed that the positive group exhibited low levels of growth parameters, hemoglobin, iron and high level of aluminum as compared to normal control, while the treated groups revealed significant improvements in these parameters. Concerning antioxidant parameters, the three treated groups showed significant increases in superoxide dismutase, glutathione and total protein and significant decreases in malondialdehyde and acetylcholine esterase in their serum and brains as compared to positive control. However, the β-amyloid level decreased while RNA and DNA contents increased significantly in brains of the treated rats in comparing with the positive control. The mixture juice exhibited the best protective effect among the three juices against aluminum toxicity, so it is important for those who suffering from aluminum toxicity.