Cinnamon is used in the medical field for the treatment of many diseases, especially those related to liver disease. This study aimed to assess the effective compounds of cinnamon water extract and its role in protecting against liver disease in experimental rats. The liver cirrhosis was induced by carbon tetrachloride (CCl₄). In rats with liver cirrhosis caused by CCl₄ were observed to have elevated liver enzymatic activity in serum. The elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were significantly enhanced to nearly normal after administering oral cinnamon aqueous extract at a dose of 0.6 ml / 100 g body weight/day for 12 consecutive weeks. There was a significant rise in the serum Malondialdehyde (MDA), while the activities of reduced glutathione (GSH), albumin and total proteins decreased significantly in rats treated with CCl₄. Cinnamon aqueous extract has a protective effect on the liver by lowering the level of MDA and elevating the activities of GSH, total proteins and serum albumin. The histological examination of the liver confirmed the enhancement effect in the studied liver biomarkers. In conclusion, the high content of phytochemicals in cinnamon aqueous extract may be considered as the main cause of the protective properties against liver disease.