In Egypt, fenugreek seeds are considered one of the most important crops belongs to family Fabaceae and it is major producing in most of the developing countries. In this biological study using fenugreek seeds boiled drink "FSB", deodorized fenugreek seeds with water boiled drink "DFSWB" and deodorized fenugreek seeds with anise water boiled drink "DFSAB". The results indicated that serum glucose in diabetic rats was reduced from 382.680 to 300.163 mg/dl, when the rats were fed on deodorized fenugreek seeds with water boiled drink. This means that the decrease of serum glucose was 82.517 mg/dl in diabetic rats after treatments for 5 weeks. Treatments the rats with deodorized fenugreek seeds with water boiled drink "DFSWB" and deodorized fenugreek seeds with anise-water boiled drink "DFSAB" for 35 days decreased the serum glucose significantly but gradually. The rate of increasing in serum Insulin reached from less than 0.02µUI/ml to 0.477, 0.653 and 0.537 µUI/ml when using fenugreek seeds boiled drink "FSB", deodorized fenugreek seeds with water boiled drink "DFSWB" and deodorized fenugreek seeds with anise-water boiled drink "DFSAB", respectively.