The present studyis conducted to evaluate the preventive effects of some natural plants such as Turmeric (Curcuma Longa Linn) powder and garlic(Allium sativum)powder on rat feed on high fat diet. Twenty fourmale albino rats each weighing 130±10 g,was divided into 4 groups .Group (1) negative control group feeding basal diet, Group ( 2 ) positive control group fed in high fat diet,Group (3)hypercholesterolemic rats fed on basal diet containing 10%  garlic andGroup ( 4) hypercholesterolemic rats fed onbasal diet containing 10% turmeric. At the end of experiment, the four groups were compared in terms of the proportion of fat in the blood , serum biomarkers of liver tissue injury and the activities of antioxidant enzymes in liver tissue. The results indacted that,high fat diet caused deleteriousmetaboliceffects, includinghypertriglyceridemia,hypercholesterolemia and liver dysfunction. Rats fed high fat diet alone showed increased activities of hepatocellular enzymes in plasma, significant decline in antioxidants, and elevated lipid peroxidation indices in liver. Turmeric treatment significantly reduced elevated markers of liver tissue injury and lipid peroxidation product , and brought back the liver antioxidants and the over accumulation lipids in serum towards normal. The results obtained showed turmeric powder had a protective effects against hepatic steatosis. Also results showed that garlic significantly reducedtotal cholesterol (TC), plasma triglyceride (TG), LDL-c, VLDL-c, liver triglyceridesand elevated plasma antioxidant in garlic treated rats groups ( 3 ) compared to group ( 2 ). Also, liver  activity was decreased in group ( 3 )  than group ( 2 ) .Therefore, the results are clearly indicative of the beneficial effects of turmeric and garlic in reducing lateral side effects of hyperlipidemia.