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253126

The validity of giving adjuvant capecitabine after standard anthracycline and/or taxanes based neo-/adjuvant chemotherapy in early triple-negative breast cancer patients: An Egypt

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Cell-based therapy against cancer

Abstract

Background: Triple-negative breast cancer (TNBC) is considered an aggressive breast cancer subtype despite giving standard therapies, these patients have high metastatic and relapse rates in addition to short survival. Therefore, we conducted this trial to study the validity of giving adjuvant Capecitabine, after receiving standard neoadjuvant /adjuvant chemotherapy in operable TNBC patients. The primary end point was disease-free survival (DFS) and secondary end points were overall survival (OS) and safety profile. Material and Methods: The 89 eligible patients were randomly assigned into two groups (A “Capecitabine arm" and B “observation arm") after receiving neo/adjuvant anthracycline and/or taxanes-containing chemotherapy. Results: 78.7% were invasive duct carcinoma (IDC), and a median age was 48 years. 50.6% were node positive patients. 79.5% received adjuvant anthracyclines and taxanes chemotherapy protocol for group A and (75.6%) for group B. (56.2%) underwent breast-conservative surgery. regarding 4-year disease free survival (DFS), there was statistically significant difference between both groups (P = 0.032) and 4-y overall survival (OS) (P = 0.050)) with an acceptable toxicity profile in the Capecitabine arm. Conclusions: Our study showed statistically significant increase in DFS and OS after giving adjuvant Capecitabine to standard Neo-/Adjuvant chemotherapy in early TNBC patients with acceptable toxicity of Capecitabine arm. However, a larger study with more number of patients is recommended to give more statistical powered results.

DOI

10.21608/jcbr.2022.125666.1255

Keywords

Triple-negative breast cancer, Capecitabine, adjuvant chemotherapy, Survival, safety profile

Authors

First Name

lobna

Last Name

Abdelaziz

MiddleName

A.

Affiliation

Clinical Oncology and Nuclear Medicine Department,Zagazig University,Zagazig ,Egypt

Email

mmlobna90@gmail.com

City

cairo

Orcid

0000-0001-6082-2856

First Name

Ahmed

Last Name

Hefni

MiddleName

mubarak

Affiliation

Medical Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut

Email

ahmed_mubarak1982@aun.edu.eg

City

Assiut

Orcid

-

First Name

Alia

Last Name

Attia

MiddleName

M.

Affiliation

Department of Radiation Oncology, South Egypt Cancer Institute, Assiut University, Egypt,

Email

aliamohamadattia@yahoo.com

City

Assiut

Orcid

-

First Name

loay

Last Name

Gertalla

MiddleName

-

Affiliation

Surgery Department, Faculty of medicine, Zagazig University, Egypt.

Email

loayelhady@gmail.com

City

Zagazig

Orcid

-

First Name

Marwa

Last Name

Abdelgawad

MiddleName

-

Affiliation

Associate Professor of clinical Oncology Department,Assiut University

Email

esmailmarwa@yahoo.com

City

Assiut

Orcid

0000-0002-0919-2489

Volume

6

Article Issue

2

Related Issue

36020

Issue Date

2022-06-01

Receive Date

2022-03-06

Publish Date

2022-06-01

Page Start

67

Page End

77

Print ISSN

2682-261X

Online ISSN

2682-2628

Link

https://jcbr.journals.ekb.eg/article_253126.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=253126

Order

7

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

The validity of giving adjuvant capecitabine after standard anthracycline and/or taxanes based neo-/adjuvant chemotherapy in early triple-negative breast cancer patients: An Egyptian prospective multicentric phase III trial

Details

Type

Article

Created At

22 Jan 2023