Increased disease susceptibility in some communities is problematic for health planners and providers. The previous gene-behavior theory outlined a causal relationship between behavior and disease susceptibility in non-coding satellite DNA. While this theoretical viewpoint requires further thought to know more about this relationship; it does provide a platform for further rigorous research. In this review, glycosylation was reviewed from a new perspective, thus we focused and tracked its association with satellite DNA and cancer susceptibility using sequential reasoning. Our model suggests glycosylation is a major tangible action of satellite DNA alterations caused by behaviors. Our model also suggests glycosylation is influenced by genetic anticipation. In addition, glycosylation patterns may function as behavioral biomarkers for the social sciences, community-targeted approaches, and early prognostic tools for behavioral-related pathogenesis. These notions open up new avenues for behavioral immunogenetics and behavioral epidemiology areas. Therefore, more in-depth and improved treatment strategies are required,especially for cancer.