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197887

Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Cancer and microbiome

Abstract

Background: The biology of breast cancer was shown to vary in different ethnic populations. Fibronectin (FN) and laminin (LN) are adhesive glycoproteins present in the extracellular matrix (ECM) and have been shown to associate with prognosis of breast cancer patients. However, their prognostic values have not been fully studied. Aim: We aim to study the prognostic values of FN and LN in breast cancer patients. Materials and Methods: Here, we used immunohistochemical (IHC) staining to investigate the expression patterns of FN and LN in 77 breast cancer patients and to evaluate their prognostic values. Results: High expression levels of FN and LN were detected in 72.7% and 67.5% of cases, respectively. High FN expression was associated with longer overall survival (OS) and disease-free survival (DFS). Moreover, multivariate analysis showed that FN is an independent prognostic factor for OS and DFS. No significant associations detected between LN expression and clinicopathological parameters or survival data. Conclusion: Our results suggest that FN and LN biomarkers biologically function differently in breast cancer.

DOI

10.21608/jcbr.2021.63387.1176

Keywords

reast cancer, Fibronectin, Immunohistochemistry, Laminin, prognostic marker

Authors

First Name

Mohamed

Last Name

Kamal

MiddleName

-

Affiliation

Stem Cell and Regenerative Medicine Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California (USC) Room 3514, Norris Research Tower, 1441 Eastlake Ave, Los Angeles, UAS.

Email

salehm@usc.edu

City

-

Orcid

0000-0001-8663-8846

First Name

Mohamed

Last Name

El-Gerbed

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Damanhour University, Damanhour, Egypt.

Email

m.elgerbed@yahoo.com

City

-

Orcid

-

First Name

Aml

Last Name

Talaat

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Damanhour University, Damanhour, Egypt.

Email

amolasho@yahoo.com

City

-

Orcid

-

First Name

Karoline

Last Name

Abdul-aziz

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Damanhour University, Damanhour, Egypt.

Email

abdoul-aziz@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Shalaby

MiddleName

-

Affiliation

Department of Oncologic Pathology, Damanhour National Medical Institute, Damanhour, El-Behera, Egypt.   Pathology Department, Faculty of Medicine, Nagasaki University, Japan.  

Email

shalaby@yahoo.com

City

-

Orcid

-

First Name

Rasha

Last Name

Khedr

MiddleName

-

Affiliation

 Department of clinical Oncology, Faculty of Medicine, Tanta University, Tanta, Egypt. 

Email

khedr@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Salem

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.

Email

mohamed.labib@science.tanta.edu.eg

City

Egypt

Orcid

0000-0001-9454-6327

Volume

5

Article Issue

4

Related Issue

29244

Issue Date

2021-12-01

Receive Date

2021-02-15

Publish Date

2021-12-01

Page Start

135

Page End

145

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 4_Pages 135-145.pdf

PDF . 7.8MB

Link

https://jcbr.journals.ekb.eg/article_197887.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=197887

Order

11

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023