ManageChatDiscover
197892

Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Physiology

Abstract

Background:Rosemary (ROLE) and costus (SLRE) have been established to show antioxidant effects. Aim: This study aimed to evaluate the ameliorating effects of ROLE and SLRE to the side-effects induced by cisplatin (CIS) in tumor-bearing mice. Materials and Methods: Extracts of ROLE and SLRE were examined for their phytochemical activities. To ecaluate their anti-tumor effects, mice were inoculated intraperitoneally (i.p.) with 2.5x105 Ehrlich ascites carcinoma (EAC) and then treated i.p. with CIS (dose????) at days 3-7 and with ROLE (dose) or SLRE (dose) at days 3-14. Mice were sacrificed on day 14 for CBC and T-cell analyses. Results: Phytochemical analysis revealed that both ROLE and SLRE showed similar antioxidant activities. Treatment of EAC-bearing mice with CIS induced antitumor efficacy of about 90%.  Treatment with CIS in combination of ROLE or SLRE  did not further enhance the the antitumor activity of CIS. However, co-administration of ROLE or SLRE with CIS increased significantly the antitumor efficacy of CIS. Flow cytometric analysis showed that the numbers of CD4+ and CD8+ T cells were decreased in EAC bearing mice after treatment with CIS. Treatment with both ROLE and SLRE improved the number of these cells. Conclusion: Combinatorial treatment with rosemary and costus

DOI

10.21608/jcbr.2021.84374.1219

Keywords

CBC, Cisplatin, costus, Ehrlich ascites, lymphocytes, rosemary, Tumor

Authors

First Name

Yousry

Last Name

El-Bolkiny

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.

Email

bolkiny61@yahoo.com

City

Tanta

Orcid

0000-0003-4001-6034

First Name

Mohamed

Last Name

Salem

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.

Email

mohamed.labib@science.tanta.edu.eg

City

Egypt

Orcid

0000-0001-9454-6327

First Name

Sabry

Last Name

El-Naggar

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.

Email

sabry_elnaggar@yahoo.com

City

Tanta

Orcid

0000-0002-7018-9350

First Name

Fatma

Last Name

El-Sharkawy

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.

Email

fatma.elsharkawy@science.tanta.edu.eg

City

El-Santa

Orcid

-

Volume

5

Article Issue

4

Related Issue

29244

Issue Date

2021-12-01

Receive Date

2021-07-06

Publish Date

2021-12-01

Page Start

85

Page End

98

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 4_Pages 85-98.pdf

PDF . 3.3MB

Link

https://jcbr.journals.ekb.eg/article_197892.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=197892

Order

7

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin

Details

Type

Article

Created At

22 Jan 2023