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163639

Early onset gastric cancer in Egyptian patients: Is it really a different clinical entity?

Article

Last updated: 04 Jan 2025

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Tags

Computational based cancer therapy

Abstract

Background: Little is known about characteristics of young patients with gastric carcinoma (GC) in Egypt. Aim: The purpose of this study was to define the clinicopathological features and survival of young GC patients in our population. Patients and Methods: We retrospectively analyzed data of 197 GC patients who were treated at our institution from 2011 to 2016. The clinicopathological characteristics and survival were compared between 61 young (≤45 years) and 136 older (>45 years) GC patients. We also studied variables impacting survival of younger patients. Results: The proportion of females, positive family history, and poorly differentiated tumors were significantly higher in young patients. Younger group showed significantly longer interval between symptoms and diagnosis (all P < 0.05). The mean overall survival (OS) of young patients was lower compared to older patients (10.7 vs. 18.7 months, respectively; P=0.06). Multivariate analyses revealed that distant metastasis and CA19-9 were independent factors for reduced survival in younger patients. Conclusion: We conclude that clinico-pathological characteristics of GC are different between young and old patients. Aggressive tumor biology and a significant diagnostic delay may have contributed to worse survival in younger patients.

DOI

10.21608/jcbr.2020.48678.1089

Keywords

Gastric carcinoma, young age, Clinicopathological features, prognosis

Authors

First Name

Ahmed

Last Name

Ramez

MiddleName

M.

Affiliation

Medical Oncology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

dr_ramez522@hotmail.com

City

-

Orcid

0000-0002-0318-1543

First Name

Maha

Last Name

El-Zaafarany

MiddleName

-

Affiliation

Medical Oncology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

maha15866@hotmail.com

City

-

Orcid

-

First Name

Hayam

Last Name

Ghazy

MiddleName

-

Affiliation

Medical Oncology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

doddah_125@yahoo.com

City

-

Orcid

-

First Name

Basel

Last Name

Refky

MiddleName

-

Affiliation

Surgical Oncology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

dr.basel@hotmail.com

City

-

Orcid

-

First Name

Amany

Last Name

Hassan

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

dramanyhassan@mans.edu.eg

City

-

Orcid

-

First Name

Manar

Last Name

Hamed

MiddleName

-

Affiliation

Medical Oncology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

hamedmanar9@gmail.com

City

-

Orcid

-

Volume

5

Article Issue

2

Related Issue

24923

Issue Date

2021-06-01

Receive Date

2020-11-03

Publish Date

2021-06-01

Page Start

173

Page End

180

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 2_Pages 173-180.pdf

PDF . 2.5MB

Link

https://jcbr.journals.ekb.eg/article_163639.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=163639

Order

16

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

Early onset gastric cancer in Egyptian patients: Is it really a different clinical entity?

Details

Type

Article

Created At

22 Jan 2023