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163638

The role of Her 2 neu and N-cadherin expression in hepatocellular carcinoma

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Last updated: 04 Jan 2025

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Tags

Cell-based therapy against cancer
Novel Conventional chemotherapy

Abstract

Background: Despite advances in diagnosis and surgery, p < /span>atients with hepatocellular carcinoma (HCC)show bad prognosis and high recurrence rate. Therefore, it is important to search for new targeted therapy and prognostic markers. Aim: To evaluate the expression levels of Her2 neu and N-cadherin in HCC and whether they could be used as prognostic markers. Materials and Methods: This retrospective study included 40 HCC specimens retrieved from the archival cases of Pathology Department, National liver institute, Menoufia University, Egypt, spanning the period between January 2010 to December 2017. Overall survival time was available for 28 patients only. All specimens were stained by Her2 neu and N-cadherin antibodies using the streptavidinbiotin- peroxidase technique. Results: There was significant association between high Her2 neu expression and good prognostic parameters as absent lymphovascular invasion, low grade (P value = 0.028 and 0.049 respectively) and also was associated with low pathological stage but the results didn't reach the level of significance. However there was significant association between low N-cadherin score of expression and good prognostic parameters as low grade (p value = 0.022). Also, there is inverse association between Her 2 neu and N- Cadherin expression in HCC (P value = 0.000). Conclusion:  The anti-Her 2 target therapy might not be valuable for HCC patients and also larger studies are recommended to explore potential alternative targeted Her2 enhancer or promoter as well as to understand the exact biological role of Her 2 neu in HCC. 

DOI

10.21608/jcbr.2020.48042.1087

Keywords

Hepatocellular carcinoma, Her 2 neu, Immunohistochemistry, N-Cadherin, prognosis

Authors

First Name

Aiat

Last Name

Hemida

MiddleName

-

Affiliation

Pathology department, Faculty of medicine, Menoufia University.

Email

ayat_shaban@yahoo.com

City

Shebin, El Kom

Orcid

-

First Name

Dina

Last Name

Elazab

MiddleName

Shehata

Affiliation

Pathology department, National liver institute, Menoufia University

Email

delazab@yahoo.com

City

Shebin, El Kom

Orcid

-

First Name

Nanis

Last Name

holah

MiddleName

Shawky

Affiliation

pathology department, faculty of medicine, menoufia university, Egypt

Email

shawkyholah@yahoo.com

City

Shebin, El Kom

Orcid

-

Volume

5

Article Issue

2

Related Issue

24923

Issue Date

2021-06-01

Receive Date

2020-10-28

Publish Date

2021-06-01

Page Start

161

Page End

172

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 2_Pages 161-172.pdf

PDF . 9.6MB

Link

https://jcbr.journals.ekb.eg/article_163638.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=163638

Order

15

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

The role of Her 2 neu and N-cadherin expression in hepatocellular carcinoma

Details

Type

Article

Created At

22 Jan 2023