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163846

Role of expression of p53 and Ki67 in the progression of Wilms tumor: Correlation with patients’ survival

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Cellular and molecular targeting

Abstract

Background: Wilms tumor (WT) is the most frequent renal tumor of childhood and is a highly responsive tumor to chemotherapy. P53 and ki67 are two of the most important markers that have been evaluated in many cancers. The role of p53 in the pathogenesis and progression of WT is only partly understood. Over the past decade, the importance of Ki-67 in the prognosis of breast cancer has been widely studied. On the other hand, fewer studies are available for this in WT. Aim: To study the possible role of p53 and ki67 in the progression and outcome of Wilms tumor cases. Methods: Immunohistochemical (IHC) staining for p53 and ki67 were done and correlated with clinicopathological data of Wilms tumor cases. Results: There was a positive correlation between p53 and ki67 expression and unfavorable histology, higher tumor stage, shorter disease-free survival (DFS) and overall survival (OS). Conclusion: Ki67 and p53 expression was positively correlated with aggressive behavior of Wilms tumor

DOI

10.21608/jcbr.2021.46401.1081

Keywords

Wilms tumor, anaplasia, p53, Ki67

Authors

First Name

Ahmad

Last Name

Darwish

MiddleName

-

Affiliation

Pediatrics department, Hematology/Oncology and Bone Marrow Transplantation unit, Mansoura Faculty of Medicine, Mansoura, Egypt.

Email

ahmad_darwish_77@yahoo.com

City

Mansoura

Orcid

-

First Name

Doaa

Last Name

Alemam

MiddleName

-

Affiliation

Public Health and Community department, Mansoura Faculty of Medicine, Mansoura, Egypt.

Email

dr_doaashokry@hotmail.com

City

-

Orcid

-

First Name

Heba

Last Name

Sheta

MiddleName

-

Affiliation

Pathology department, Mansoura Faculty of Medicine

Email

heba_sheta@yahoo.com

City

-

Orcid

0000-0002-4771-1120

Volume

5

Article Issue

2

Related Issue

24923

Issue Date

2021-06-01

Receive Date

2020-10-14

Publish Date

2021-06-01

Page Start

99

Page End

110

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 2_Pages 99-110.pdf

PDF . 3.2MB

Link

https://jcbr.journals.ekb.eg/article_163846.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=163846

Order

9

Type

Letter to the Editor

Type Code

1,236

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

Role of expression of p53 and Ki67 in the progression of Wilms tumor: Correlation with patients’ survival

Details

Type

Article

Created At

22 Jan 2023