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164692

Management of locally advanced periampullary tumor: Multicenter study

Article

Last updated: 22 Jan 2023

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Tags

Computational based cancer therapy

Abstract

Background: Pancreas may develop either benign or malignant tumors. Pancreatic cancer (PC) is one of the most lethal solid tumors which ranking as the fourth cause of cancer-related death in the United States. Aim:  To analyze the results of treatment of locally advanced pancreatic cancer to come up with management strategy. Patients and Methods: Patients (n=136) were retrospectively evaluated with periampullary carcinoma where 40 patients were diagnosed as locally advanced periampullary carcinoma, from January 2010 to January 2018 in multicenter. Results: Patients diagnosed as pancreatic head carcinoma in 20/40 and periampullary carcinoma in 20/40 of patients, all patients were diagnosed as locally advanced pancreatic cancer by radiological imaging, where 28/40 (70%) was males and 12/40 (30%) were females with male:female ratio of 2.3:1. The age of patients at diagnosis was 39-62 years with a median age of 51 years. All patientswere = evaluated and followed up for 24 months with Multislice CT, PET-CT and tumor markers. Some patients underwent neoadjuvant treatment for down staging and were then surgery was done for 25/40 cases. Whipple's operation without VR in 17/25 and VR done in 8/25 cases, where 6/40 cases died during chemotherapy and 9/40 unfit for surgery due to disseminated disease and complications of chemotherapy. Conclusion: Pancreatic cancer patients diagnosed as locally advanced or metastatic tumor need MDT to decide different modes of treatment in order to obtain better results

DOI

10.21608/jcbr.2021.45222.1075

Keywords

Chemotherapy, locally advanced pancreatic carcinoma, Pancreatic carcinoma, vascular resection

Authors

First Name

Essam

Last Name

Elshikh

MiddleName

-

Affiliation

Surgical Oncology Department, Tanta Cancer Center, Tanta, Egypt

Email

essam.elshikh@gmail.com

City

kafr alsheikh

Orcid

00000000174168103

First Name

Taha

Last Name

Yassein

MiddleName

-

Affiliation

Surgery Department, NLI, Menufia university, Menufia, Egypt

Email

tahayassin13@yahoo.com

City

-

Orcid

-

First Name

Eslam

Last Name

Ayoub

MiddleName

-

Affiliation

Surgery Department, NLI, Menufia University, Menufia, Egypt

Email

eslam.ismail12@liver.meofia.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Ebeed

MiddleName

-

Affiliation

Radiodiagnosis Department, Tanta Cancer Center, Tanta, Egypt

Email

drahmedebeed@yahoo.com

City

-

Orcid

-

First Name

Hossam Elashtokhy

Last Name

Hossam Elashtokhy

MiddleName

-

Affiliation

Medical Oncology Department, Tanta Cancer Center, Tanta, Egypt

Email

hossam_105@hotmail.com

City

-

Orcid

-

First Name

Walla

Last Name

Abdelgawad

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Suez University, Suez, Egypt.

Email

walaagg78@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Elsabrout

MiddleName

-

Affiliation

Surgical Oncology Department, Tanta Cancer Center, Tanta, Egypt

Email

elsabrout60@hotmail.com

City

-

Orcid

-

First Name

Mosad

Last Name

El-lity

MiddleName

-

Affiliation

Pathology Department, Tanta Cancer Center, Tanta, Egypt

Email

mosadelity@gmail.com

City

-

Orcid

-

First Name

Tarek

Last Name

Youssef

MiddleName

-

Affiliation

Surgical Oncology Department, Tanta Cancer Center, Tanta, Egypt

Email

dr_tareksalah77@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Ibrahim

MiddleName

-

Affiliation

General Surgery Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt

Email

mohamedibrahim555@hotmail.com

City

-

Orcid

0000-0001-6239-8147

Volume

5

Article Issue

2

Related Issue

24923

Issue Date

2021-06-01

Receive Date

2020-10-18

Publish Date

2021-06-01

Page Start

67

Page End

79

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 2_Pages 67-79.pdf

PDF . 3.1MB

Link

https://jcbr.journals.ekb.eg/article_164692.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=164692

Order

7

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023