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114304

Inflammatory mediator modulation by Short- and Long-Acting β2 Agonists in Induced Bronchial Asthma in Rats

Article

Last updated: 04 Jan 2025

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Tags

Cellular and molecular targeting
Novel in vitro assessment models

Abstract

Background: Bronchial asthma is an inflammatory lung disease characterized by hyper-responsiveness and bronchoconstriction. Beta2 agonists are bronchodilator drugs that possess anti-inflammatory properties. Aim: The present study aimed to investigate the anti-inflammatory and anti-oxidant effects of short-acting (salbutamol) and long-acting(bambuterol) as beta 2 agonists combination. Also, the effect of these drugs, singly and in combination with prednisolone was measured in asthma-induced rats in both lung tissue and broncho-alveolar lavage. Materials and Methods:Wistar rats were sensitized with intraperitoneal (I.P) administration of ovalbumin/Al(OH)3, twenty days later, animals were treated orally with salbutamol 2mg/kg or bambuterol 10 mg/kg or prednisolone 3mg/kg or a combination.  Results: Ovalbumin/Al(OH)3-sensitized rats showed a significant elevation in inflammatory mediators (IL-4, MIP1α, PGE2, TNFα) and other oxidative parameters such as MDA, NO in both lung tissue and bronchial alveolar lavage (BAL). Moreover, salbutamol and bambuterol decreased inflammatory mediators and alleviated oxidative stress. These inhibitory effects were greatest when both short and long-acting β2 agonists were used in combination. Also, co-administration of β2 agonists with prednisolone revealed pronounced decreases in all parameters compared to β2 agonists alone. Conclusion: The combined therapy of salbutamol and bambuterol has an anti-inflammatory and anti-oxidant effect on the experimentally induced asthma in both BAL fluids and lung tissues. Also, these drugs in combination with prednisolone possess greater inhibitory effects on inflammatory mediators.

DOI

10.21608/jcbr.2020.39759.1063

Keywords

bronchial asthma, β2 agonists, Inflammatory mediators, glucocorticoids

Authors

First Name

Nageh

Last Name

EL-Mahdy

MiddleName

A.

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt

Email

-

City

-

Orcid

-

First Name

Shady

Last Name

Allam

MiddleName

-

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

Email

-

City

-

Orcid

-

First Name

Sara

Last Name

El Sayaad

MiddleName

-

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Tanta University, Tanta, Egypt

Email

sara-elsayaad@hotmail.com

City

-

Orcid

-

Volume

5

Article Issue

2

Related Issue

24923

Issue Date

2021-06-01

Receive Date

2020-08-18

Publish Date

2021-06-01

Page Start

39

Page End

48

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 2_Pages 39-48.pdf

PDF . 3.6MB

Link

https://jcbr.journals.ekb.eg/article_114304.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=114304

Order

4

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

Inflammatory mediator modulation by Short- and Long-Acting β2 Agonists in Induced Bronchial Asthma in Rats

Details

Type

Article

Created At

22 Jan 2023