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164790

Metformin: An AMPK-dependent antidiabetic drug with novel medical applications

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Biochemistry
Disease modeling

Abstract

Metformin (MET) is a well-known antidiabetic drug for type 2 diabetes mellitus (T2DM) treatment. The therapeutic effects of MET come from its ability to decrease both the production of hepatic glucose and its absorption via the intestine and improve insulin hormone sensitivity. This review aims to summarize the new medical applications of this old antidiabetic drug. Nowadays, MET is used in pre-clinical trials to treat cancer and slow the proliferation rate, emerging from its hypoglycemic effect and antioxidant activity. MET enhanced the functions of immune T-cells and reduced the proinflammatory mediators in macrophages. Moreover, based on the pre-clinical studies, its effect on the reproductive system is confirmed as MET showed an excellent candidate for polycystic ovary syndrome (PCOS) treatment and improved ovarian cyclicity, and reduces gestational diabetes risks in female; however, the effect on sperm number and motility is still in debate. Treatment with MET also showed some beneficial effects on bone health, and its administration led to a deficiency in vitamin B12. Furthermore, MET enhances anaerobic pathways and increases lactic acid levels. This review demonstrated the novel uses of MET in different clinical settings with explained mechanisms of action.

Keywords

Anticancer, antioxidant, anti-diabetic, Obesity, Metformin

Authors

First Name

Maysa

Last Name

Mobasher

MiddleName

Ahmed

Affiliation

1-Department of Pathology, Biochemistry Division, College of Medicine, Jouf University, Sakaka, Saudi Arabia. 2-Department of Clinical Pathology, El Ahrar Educational Hospital, Ministry of Health, Zagazig, Egypt.

Email

mmobasher@ju.edu.sa

City

-

Orcid

0000-0003-2987-0387

Volume

5

Article Issue

2

Related Issue

24923

Issue Date

2021-06-01

Receive Date

2021-03-23

Publish Date

2021-06-01

Page Start

1

Page End

12

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 2_Pages 1-12.pdf

PDF . 1.7MB

Link

https://jcbr.journals.ekb.eg/article_164790.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=164790

Order

1

Type

Review Article

Type Code

1,231

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023