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169397

Antioxidant and antidiabetic activities of some algal species: Thesis Abstract

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Natural/synthetic agents in anti-cancer therapy

Abstract

Background: Algae are known to have active ingredients that have anti-oxidant activities that might have biological importance. Aim: Antioxidant and antidiabetic activities of some algal species. Materials and Methods: In this study different crude extracts of two microalgae Spirulina platensis, Chlorella vulgaris and six seaweeds Turbinaria decurrens, Padina pavonica, Sargassum muticum and Sargassum acinarium; Ulva lactuca as well as Pterocladia capillacea were tested to evaluate their antioxidant properties and in vitro antidiabetic potential on α-amylase and α-glucosidase enzymes. Results: The phytochemical screening of these extracts showed the presence of bioactive compounds that responsible for the antioxidant and antidiabetic activities. In addition, all analyzed extracts exhibited antioxidant activity using DPPH, reducing power and total antioxidant capacity assays in addition to antidiabetic activity. Among these extracts, S. platensis methanolic extract and T. decurrens acetone extract exhibited the highest antioxidant activity and inhibitory effects on α-amylase and α-glucosidase; which was related with its total phenolic content. Both extracts showed no toxicity on normal cell lines using MTT assay. GC-MS analysis of the S. platensis ME and the T. decurrens AE revealed the presence of different bioactive compounds. Concerning the in vivo study, both S. platensis ME and T. decurrens AE at different doses caused anti-hyperglycaemic activity by reducing the blood glucose level. A remarkable decrease in different liver and kidney functions and hyperlipidemia related to diabetes. The algal extracts treatment also showed enhancement of body weight loss and improvement of the total protein, albumin and hemoglobin levels. Furthermore, treatment of diabetic rats with the extracts caused improvement of the histopathological changes of the liver and pancreas tissues related to diabetes. Conclusion: The investigated compounds may be acted synergistically and responsible for its antioxidant and antidiabetic activities.

DOI

10.21608/jcbr.2021.59328.1125

Keywords

algae, antioxidant, antidiabetic, Gas chromatography, Mass Spectroscopy, Phytochemical

Authors

First Name

Omnia

Last Name

Abdel-Karim

MiddleName

-

Affiliation

Department of Botany and Microbiology, Faculty of Science, Tanta University, Tanta, Egypt.

Email

omnia.hamdy@science.tanta.edu.eg

City

-

Orcid

0000-0002-9149-1209

First Name

Atef

Last Name

Abo-Shady

MiddleName

Mohamed

Affiliation

Department of Botany and Microbiology, Faculty of Science, Tanta University, Tanta, Egypt.

Email

atef.aboshady@science.tanta.edu.eg

City

-

Orcid

0000-0003-0531-9689

First Name

Saly

Last Name

Gheda

MiddleName

Farouk

Affiliation

Department of Botany and Microbiology, Faculty of Science, Tanta University, Tanta, Egypt.

Email

sally.gheda@science.tanta.edu.eg

City

-

Orcid

0000-0002-4458-7945

First Name

Gehan

Last Name

Ismail

MiddleName

Ahmed

Affiliation

Department of Botany and Microbiology, Faculty of Science, Tanta University, Tanta, Egypt

Email

gehan.ismail@science.tanta.edu.eg

City

-

Orcid

0000-0002-3996-0047

Volume

5

Article Issue

0

Related Issue

24815

Issue Date

2021-05-01

Receive Date

2021-01-23

Publish Date

2021-05-01

Page Start

39

Page End

39

Print ISSN

2682-261X

Online ISSN

2682-2628

Link

https://jcbr.journals.ekb.eg/article_169397.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=169397

Order

41

Type

Essay Abstract

Type Code

1,902

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023