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164773

Molecular and immunological investigation of neuroinflammation induced by mycotoxines: Thesis Abstract

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Inflammatory and cancer

Abstract

Neuroinflammation represents the coordinated cellular response to tissue damage. Mycotoxins are low-molecular-weight natural products produced as secondary metabolites by filamentous fungi. The toxic effect of mycotoxins on animal and human health is referred to as mycotoxicosis, Fusarium species are the main pathogenic fungi causing maize ear and kernel rot worldwide, mainly produce fumonisin B (FB) that contaminate grains and grain products.
In this study, fungi were isolated from corn seeds and ethanolic natural product crude extracts were used as antifungal compounds. Antifungal effects of three extracts were assessed in vitro on toxin production and different toxin concentrations (in vitro study). A newly identified sequence was registered to our study group and was given a new accession number by GenBank. The inhibitoriest effect for the production of fumonisin B1 was for Cinnamuom zeilanicum followed by Berberise vulgaris and finally Calluna vulgaris.
Gene expression by Real time PCR the fold change calculated values for the assessment of IL-1β,COX II, iNOS and TNF-α gene expressions showed at P

DOI

10.21608/jcbr.2021.61334.1161

Keywords

Cinnamon zeilanicum, Fusarium sporotrichioides, Mycotoxins, Natural product, neuro-inflammatory

Authors

First Name

nadia

Last Name

ismail

MiddleName

fouad

Affiliation

Lecturer, Medical laboratory technology Department, Faculty of Allied Medical Sciences, Pharos University in Alexandria, Alexandria. Egypt.

Email

nadia.elyas@pua.edu.eg

City

-

Orcid

-

First Name

mohamad

Last Name

El-Saied

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria Egypt.

Email

mmaelsayed1@yahoo.com

City

alexandria

Orcid

-

First Name

maha

Last Name

el demellawy

MiddleName

-

Affiliation

Medical Biotechnology Department (MBD), Genetic Engineering and Biotechnology Research Institute (GEBRI), Pharmaceutical & Fermentation Industries Development Center (PFIDC),City for Scientific Research and Technology Applications (SRTA-City)

Email

m.eldemellawy@srtacity.sci.eg

City

alexandria

Orcid

-

First Name

Doaa

Last Name

Ghareeb

MiddleName

-

Affiliation

Prof. of Biochemistry, Faculty of Science, Alexandria University, Egypt City for Scientific Research and Technology Applications (SRTA-City)

Email

d.ghareeb@yahoo.com

City

alexandria

Orcid

-

First Name

sobhy

Last Name

el sohaimy

MiddleName

-

Affiliation

Department of Food Technology, City for Scientific Research & Technology Applications, New Borg El Arab, Alexandria, Egypt

Email

sobhyelsohimy@srtacity.sci.eg

City

alexandria

Orcid

-

Volume

5

Article Issue

0

Related Issue

24815

Issue Date

2021-05-01

Receive Date

2021-02-03

Publish Date

2021-05-01

Page Start

32

Page End

32

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 0_Pages 32-32.pdf

PDF . 201.2kB

Link

https://jcbr.journals.ekb.eg/article_164773.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=164773

Order

34

Type

Essay Abstract

Type Code

1,902

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023