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158662

OCT4, Ki-67 and VEGF as Prognostic Factors in Endometrial Carcinoma and Their Role in The Differentiation between Atypical Endometrial Hyperplasia and Grade 1 Endometrial Carcinom

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Inflammatory and cancer

Abstract

Background: Endometrial carcinoma develops through preliminary stages of endometrial hyperplasia. A population of epithelial stem cells was identified in the human endometrium, these cells may serve as a source of putative endometrial carcinoma. The most important member of cancer stem cell markers is OCT-4. Both tumor cell proliferation (Ki-67) and angiogenesis seem to be important for the development of aggressive tumors. Aim of the Work: This study aimed to evaluate the expression of OCT4, Ki-67 and VEGF in endometrial hyperplasia and endometrial carcinoma and to differentiate between grade 1 endometrial carcinoma and atypical endometrial hyperplasia. Materials and Methods: 60 cases of endometrial hyperplasia and 60 cases of endometrial carcinoma were stained by OCT4, Ki-67and VEGF immunohistochemical markers. Results: OCT-4 expression was significantly increased with advanced tumor grade and stage (P value = 0.001, 0.044) respectively. There was also significant association between Ki-67 expression and advanced tumor grade and stage (P value = 0.0016, 0.049) respectively. VEGF expression was significantly increased with advanced tumor grade and stage (P value = 0.001) for both. As regards the correlation of immunohistochemical results between atypical endometrial hyperplasia versus grade 1 endometrial carcinoma cases, Ki-67 was the marker with significant relation. Conclusion: OCT-4, Ki-67 and VEGF expressions showed a positive correlation with tumor aggressive pathological parameters. The Ki-67 labelling index can be used in differentiation between endometrial hyperplasia with atypia and grade 1 endometrial carcinoma.

DOI

10.21608/jcbr.2021.52448.1101

Keywords

Endometrial, carcinoma, Hyperplasia, Ki-67, OCT4, VEGF

Authors

First Name

Noha

Last Name

El-Anwar

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt, Pathology Department, Armed Forces College of Medicine, Egypt.

Email

nohaelanwar@gmail.com

City

Tanta

Orcid

0000-0002-7961-7577

First Name

Alaa

Last Name

Amer

MiddleName

I.

Affiliation

Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

Email

alaa.amer@med.tanta.edu.eg

City

-

Orcid

-

Volume

5

Article Issue

1

Related Issue

23533

Issue Date

2021-03-01

Receive Date

2020-12-06

Publish Date

2021-03-01

Page Start

143

Page End

154

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 1_Pages 143-154.pdf

PDF . 3.9MB

Link

https://jcbr.journals.ekb.eg/article_158662.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=158662

Order

14

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

OCT4, Ki-67 and VEGF as Prognostic Factors in Endometrial Carcinoma and Their Role in The Differentiation between Atypical Endometrial Hyperplasia and Grade 1 Endometrial Carcinoma: an Immunohistochemical study

Details

Type

Article

Created At

22 Jan 2023