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114098

Adipose-derived mesenchymal stem cells ameliorate the damages induced by arsenic trioxide in the testis of rats

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Cancer Stem cells targeted therapy
Cell-based therapy against cancer
Cellular and molecular targeting
Inflammatory and cancer
Novel in vitro assessment models

Abstract

Background: Arsenic trioxide is an element present everywhere in the environment. Aim: The current investigation planned to explain the remedial impacts of adipose mesenchymal stem cells (AD-MSCs) of rats against harmful impacts of Arsenic trioxide (As2O3; As III) on the testis of rats. Materials and Methods: Sixty male rats were divided into six groups: Group (1): served as the control without any treatments. Group (2): received a daily oral dose of HCL (0.5 mg/kg b.w). Experimental groups (3 and 4) received a low dose (3mg/kg b.w) of As III and groups (5,6) received a high dose (15 mg/kg b.w) of As III. The rats were sacrificed after 15 days in groups (3,5). Groups (4,6) were injected with (0.6×106) AD-MSCs / 0.5 ml PBS immediately after 15 days of oral doses of As III in low and high dose then sacrificed 7 days after MSCs injection. Results: The results indicated that AD-MSCs decreased the levels of p53 and Bax and increased the level of Bcl2. Additionally, treatment with AD-MSCs rescued the toxicity of low and high doses (L &H) As III induced change in TNF-α, IL-6, and IL-10 levels. In addition, As III L &H + AD-MSCs administration resulted in the gradual elevation of CD44 mRNA compared to control untreated mice. low and high doses of As III prompted histopathological damages in testis were they mostly turned around by treatment of AD-MSCs. Conclusion: The present results demonstrate that AD-MSCs got from the adipose tissue of rats can be a powerful treatment against harmfulness induced by As III in testis.

DOI

10.21608/jcbr.2020.38276.1060

Keywords

Arsenic trioxide, apoptosis, Adipose Mesenchymal Stem Cells, Cytokines, testis injury

Authors

First Name

Mona

Last Name

Atia

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Assiut University, Assiut , Egypt

Email

monatia@aun.edu.eg

City

Assiut

Orcid

0000-0002-0660-0985

Volume

5

Article Issue

1

Related Issue

23533

Issue Date

2021-03-01

Receive Date

2020-08-06

Publish Date

2021-03-01

Page Start

109

Page End

122

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 1_Pages 109-122.pdf

PDF . 6.1MB

Link

https://jcbr.journals.ekb.eg/article_114098.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=114098

Order

11

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

Adipose-derived mesenchymal stem cells ameliorate the damages induced by arsenic trioxide in the testis of rats

Details

Type

Article

Created At

22 Jan 2023