Background: Psoriasis is a complex immune-mediated inflammatory disease that occurs in a genetically susceptible individual. Aim: In this study, we aimed to test whether the use of autovaccine containing different attenuated inflammatory cells could ameliorate the inflammatory process in a psoriasis-like skin inflammation model. Materials and methods: After six days of IMQ application, the psoriasis-like skin inflammation was developed. After six days of IMQ application, the psoriasis-like skin inflammation was developed. Results: After seven days of treatment (14 days of IMQ), the mice treated with the autovaccine showed the most significant improvement as reflected by PASI score. Treatment with autovaccine also induced the best significant decrease of the epidermal thickness as compared to the other treatments (P<0.01), where the complete disappearance of prurigo nodularis like skin lesions was observed. Conclusion: Taken our results together, it can be suggested that autovaccination by the attenuated inflammatory cells found in skin lesions of psoriasis-like inflammation can be a therapeutic modality for such kind of inflammatory reaction.