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158661

Blocking angiotensin pathway induces anti-fibrotic effects in a mouse model of schistosomiasis by decreasing egg burden and granulomatous reaction

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Cellular and molecular targeting

Abstract

Background: Schistosoma mansoni infection is associated with hepatic fibrosis and portal hypertension. Previous studies reported that blocking some components of rennin angiotensin system can ameliorate the liver pathology induced by S. mansoni infection. Aim: The present study investigated the potential effect of losartan, an angiotensin II receptor antagonist, and enalapril, an angiotensin-converting enzyme inhibitor, on hepatic fibrosis caused by S. mansoni in a murine model. Materials and Methods: S. mansoni-infected mice were treated at week 5 after infection with losartan, enalapril, or their combination. A group of infected mice was treated with the reference drug praziquantel (PZQ) as controls. Parasitological and histological parameters were investigated. Results: Our results showed that when compared with enalapril, treatment with losartan alone caused a considerable decrease in liver index (28.92% versus 25.09%), spleen index (47.19% versus 37.08%), worm burden (38.7% versus 24.8%), hepatic tissue egg load (62.7% versus 54%), granuloma size (40.4% versus 29.4%) and fibrosis (48.7% versus 29.4%). The combination of losartan and enalapril did not produce a more pronounced effect than those of losartan. Conclusion: Our results suggest the promising effect of enalapril and losartan in amelioration of hepatic pathology but further studies to determine their effects in combination with other antischistosomal agents such as praziquantel are recommended.

DOI

10.21608/jcbr.2020.50844.1098

Keywords

angiotensin, docking, fibrosis, Liver, Schistosoma mansoni

Authors

First Name

Heba

Last Name

El-Barabry

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Damietta University, New Damietta, 34517, Damietta, Egypt

Email

hebataha31@yahoo.com

City

-

Orcid

-

First Name

Lotfy

Last Name

Habbak

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Damietta University, New Damietta, 34517, Damietta, Egypt

Email

habbakl@du.edu.eg

City

-

Orcid

-

First Name

Basem

Last Name

Mansour

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa City, 11152, Mansoura, Egypt

Email

basem2412@yahoo.com

City

Mansoura

Orcid

0000-0001-6266-8864

First Name

Mona

Last Name

Youssef

MiddleName

Younis

Affiliation

Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.

Email

mona_younis@yahoo.com

City

-

Orcid

-

First Name

Amira

Last Name

Taman

MiddleName

-

Affiliation

Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.

Email

amirataman@mans.edu.eg

City

Mansoura

Orcid

0000-0002-4965-449X

First Name

Mohamed

Last Name

Salem

MiddleName

Labib

Affiliation

Department of Zoology, Faculty of Science, Tanta University, Tanta, 31111, Egypt

Email

mohamed.labib@science.tanata.edu.eg

City

-

Orcid

-

Volume

5

Article Issue

1

Related Issue

23533

Issue Date

2021-03-01

Receive Date

2020-11-24

Publish Date

2021-03-01

Page Start

37

Page End

48

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 1_Pages 37-48.pdf

PDF . 3.8MB

Link

https://jcbr.journals.ekb.eg/article_158661.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=158661

Order

5

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023