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158657

Protective efficiency of parsley (Petroselinum crispum) against oxidative stress, DNA damage and nephrotoxicity induced with anti- tuberculosis drugs

Article

Last updated: 22 Jan 2023

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Animal models in cancer therapy

Abstract

Background: Tuberculosis has been seen worldwide as a serious disease, one of the most adverse side effects of main anti-tuberculosis drugs is nephrotoxicity. Aim: the purpose of this research was planned To investigate the nephroprotective ability of aqueous parsley extract against Isoniazid® and Rifampicin®-induced nephrotoxicity. Materials and Methods: Adult male Wistar albino rats weighted (140-160) and they were divided randomly into four groups: 1) normal rats as a control group, 2) rats administrated with parsley extract (250 mg/kg/day), 3) rats received Isoniazid® and Rifampicin® (50 &100 mg/kg/day), and 4) rats treated with Isoniazid® and Rifampicin® In association with the extract of parsley. Results: The results showed, after six weeks, that parsley extract minimized the Isoniazid® and Rifampicin®- induced renal deterioration; This was shown by a significant decrease in serum levels of urea, creatinine, uric acid, TNF-α, IL-1β and Na+ as well as kidney MDA, nitric oxide and DNA damages. This was coupled with a significant improvement in serum calcium and K+ levels and kidney GSH and SOD activity. In addition, the histopathological results indicated that the extract succeeded in the prevention of Isoniazid® and Rifampicin® induced tissue degenerations. Conclusion: In conclusion, parsley extract may be as promising as nephroprotection against Isoniazid® and Rifampicin® nephrotoxicity through their antioxidant and radical scavenging activities.

DOI

10.21608/jcbr.2020.45551.1077

Keywords

Nephrotoxicity, Isoniazid®, Rifampicin®, DNA fragmentation, Parsley, Rats

Authors

First Name

Mahmoud

Last Name

Ashry

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University, Assuit, Egypt.

Email

mahmoud_ashry20@yahoo.com

City

-

Orcid

-

First Name

Ismail

Last Name

Atia

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University, Assuit, Egypt.

Email

dr.ismailatia@gmail.com

City

-

Orcid

-

First Name

Fatma

Last Name

Morsy

MiddleName

A.

Affiliation

Pathology Department, National Research Centre, Egypt.

Email

dr.ahmed.atia@gmail.com

City

-

Orcid

-

First Name

wael

Last Name

Elmashad

MiddleName

-

Affiliation

Physiology department, Faculty of Medicine, Tanta University, Egypt.

Email

waelelmashad@yahoo.com

City

-

Orcid

-

Volume

5

Article Issue

1

Related Issue

23533

Issue Date

2021-03-01

Receive Date

2020-10-11

Publish Date

2021-03-01

Page Start

27

Page End

36

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 5_Issue 1_Pages 27-36.pdf

PDF . 4.0MB

Link

https://jcbr.journals.ekb.eg/article_158657.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=158657

Order

4

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

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-

Details

Type

Article

Created At

22 Jan 2023