Beta
92759

Enhancement of immune tolerance of COVID-19 patients might be achieved with alginate supplemented therapy

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Cellular and molecular targeting

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a devastating pandemic virus that has neither an effective cure nor vaccine so far. Once inside the body, blood viremia increases significantly in conjunction with uncontrolled and awry immune response that induces severe unbalanced cytokine storm. This cytokine storm is initiated although the number of T lymphocyte is severely reduced alongside a damaged lymphoid tissue and systemic body inflammation. It will be a demanding need to find a natural polymer that has both anti-inflammatory and immune immune-enhancing effects that can induce the immune system to fight off the virus in a balanced manner. Alginate is a natural polysaccharide extracted from brown Algae and has been used extensively as an immune activator in different in- vivo model animals and in- vitro cell culture systems. Based on our recent experiment and other findings cited in the literature, we propose the introduction of alginate in the therapeutic regime of COVID-19 patients.

DOI

10.21608/jcbr.2020.28938.1033

Keywords

Alginate, COVID-19, T lymphocyte, Cytokine Storm

Authors

First Name

Amany

Last Name

El-Sekaily

MiddleName

-

Affiliation

Marine pollution laboratory, marine environment division, National Institute of Oceanography and Fisheries, Alexandria, Egypt.

Email

dramany_mas@yahoo.com

City

Alexandria

Orcid

-

First Name

Mohamed

Last Name

Helal

MiddleName

-

Affiliation

Marine pollution laboratory, marine environment division, National Institute of Oceanography and Fisheries, Alexandria, Egypt.

Email

m.helalf@gmail.com

City

Alexandria

Orcid

-

First Name

Aziza

Last Name

Saad

MiddleName

-

Affiliation

Applied Medical chemistry, Medical Research Institute, Elhorria Avenue, Alexandria, Egypt.

Email

saad@gmail.com

City

-

Orcid

-

Volume

4

Article Issue

Special Issue

Related Issue

16474

Issue Date

2020-06-01

Receive Date

2020-04-28

Publish Date

2020-06-01

Page Start

21

Page End

26

Print ISSN

2682-261X

Online ISSN

2682-2628

Link

https://jcbr.journals.ekb.eg/article_92759.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=92759

Order

5

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023