Background: Laryngeal tumors are considered to be the most frequent neoplasm of head and neck cancers, they account for almost 25% of the malignant neoplasms involving this region. Even though it shows better clinical outcome, its prognosis still worse due to its local invasiveness, lymph node and distant metastasis. Thus, a better realization of the molecular pathways developing laryngeal carcinogenesis may help in the identification of new predictive and prognostic biomarkers, and developing novel management strategies for this cancer. Material and methods: This study included 40 cases of laryngeal squamous cell carcinoma (LSCC), 38 cases were received as punch biopsies and only 2 cases were received as excisional biopsies. Immunohistochemical staining of all cases using P53 and PCNA was done. Results: The immunohistochemical expression of p53 was positive in the nuclei of 31 out of 40 (77.5%) LSCC cases. PCNA expression was positive in 28 out of 40 (70%) LSCC cases. P53 expression was significantly correlated with the increase in tumor size, higher tumor stageand lymph node invasion.PCNA expression, as well, was significantly correlated with the increase in tumor size, higher tumor stage, tumor grade, tumor site and lymph node invasion.Conclusions: p53 and PCNA are properly independent predictors of the outcomes in patients with LSCC, and their immunohistochemical expression may aid in predicting the clinical course in patients with LSCC, and selecting patients who should be treated more cautiously.