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96233

Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Cellular and molecular targeting
Inflammatory and cancer

Abstract

Background: Substantial evidence has supported the association between adipocytokines and many types of cancers. However, the results in the setting of colorectal cancer (CRC) remains conflicting. Aim: This study aimed to evaluate the predictive power of adipocytokines (leptin and Rrsistin) levels and abdominal fat distribution in the diagnosis of colorectal cancer. Methods: Eighty participants were recruited then divided into three groups based on the endoscopic and histopathological investigation. The recruited individuals included 30 patients with colon cancer, 25 with colonic adenoma, and 25 controls. Serum adipocytokines (leptin and resistin) levels were measured, and the quantitative fat analysis was calculated based on an abdominal CT scan. Results: Multivariable logistic regression revealed that two predictors (leptin and resistin) of CRC development could be used. Visceral/superficial fat rate was the most significant predictor among the parameters of quantitative fat analysis. Also, psoas muscle and visceral fat volume showed significant differences among the study groups. Conclusion: Leptin and resistin can be used as a valuable independent predictor for the diagnosis of colorectal cancer. Also, the visceral/superficial fat rate was the most predictor.

DOI

10.21608/jcbr.2020.28094.1029

Keywords

colorectal cancer, fat analysis, leptin, Resistin

Authors

First Name

Engy

Last Name

Shafik

MiddleName

-

Affiliation

Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Email

engyadelshafik@yahoo.com

City

Assiut

Orcid

-

First Name

Dina

Last Name

Mohareb

MiddleName

Ahmed

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Email

dinamohareb@yahoo.com

City

Assiut

Orcid

-

First Name

Helal

Last Name

Hetta

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, University, Assiut, Egypt

Email

helal.hetta@uc.edu

City

Assiut

Orcid

-

First Name

Salah

Last Name

khallaf

MiddleName

M

Affiliation

Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Assiut,Egypt.

Email

sslahmab76@yahoo.com

City

Assiut

Orcid

-

First Name

Nessren

Last Name

Abd el-Rady

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Email

nessrenmahmoud05@gmail.com

City

Assiut

Orcid

-

First Name

Zainab

Last Name

Gaber

MiddleName

-

Affiliation

Department of Tropical medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.

Email

zainabgaber@yahoo.com

City

Assiut

Orcid

-

First Name

Mohamed

Last Name

Abu Rahma

MiddleName

Zakaria

Affiliation

Department of Tropical medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.

Email

mzaburahma@yahoo.com

City

Assiut

Orcid

-

First Name

Wael

Last Name

Abbas

MiddleName

A

Affiliation

Department of Internal medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.

Email

drwaelabbas@yahoo.com

City

Assiut

Orcid

-

First Name

Haisam

Last Name

Atta

MiddleName

-

Affiliation

Department of Radiology, South Egypt Cancer Institute, Assiut University, Assiut,Egypt.

Email

haisamasa@aun.edu.eg

City

Assiut

Orcid

0000-0002-9038-0929

Volume

4

Article Issue

2

Related Issue

12003

Issue Date

2020-08-01

Receive Date

2020-04-20

Publish Date

2020-08-01

Page Start

121

Page End

131

Print ISSN

2682-261X

Online ISSN

2682-2628

Article File

JCBR_Volume 4_Issue 2_Pages 121-131.pdf

PDF . 4.0MB

Link

https://jcbr.journals.ekb.eg/article_96233.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=96233

Order

6

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023