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The association of adiponectin polymorphism (rs2241766) with susceptibility and prognosis of Egyptian patients with hematological malignancies: A case-control study

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Bioinformatics in drug discovery
Cellular and molecular targeting
Computational based cancer therapy

Abstract

Background: Haematological malignancies are ranked as the highest in incidence. Adiponectin (ADIPOQ), the most abundant circulating adipocytokine, plays a major role in the regulation of insulin sensitivity, metabolism, and hematopoiesis. Various ADIPOQ gene polymorphisms are associated with an increased risk of different cancers. However, to the best of our knowledge, the association between ADIPOQ T45G (rs2241766) single nucleotide polymorphism (SNP) and leukemia is unknown. Aim: This study aimed to investigate the association between ADIPOQ (rs2241766) and the clinicopathological status of Egyptian leukemia patients. Materials and Methods:  A case-control design was used, including 80 leukemia patients and 70 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for genotyping. Survival analysis and biochemical investigations including hematological and lipid profiles, liver and kidney functions in addition to anthropometric measurements were also determined. Results: A significant positive correlation between ADIPOQ gene T45G (rs2241766) SNP and leukemia incidence was detected. The G allele was more frequent in leukemia patients compared to the T allele. Kaplan-Meier analysis revealed that the SNP rs2241766was associated with the patient's event-free survival but not the overall survival. In addition, G carriers, hyperglycemia, and hyperuricemia patients had a significantly shorter median EFS compared with T carriers, normoglycaemia, and normoglycemia patients. Conclusion: The current study shows an association between the SNP (rs2241766) and leukemia incidence and prognosis in Egyptian patients. Furthermore, an association between the rs2241766 and high prevalence of hyperglycemia and dyslipidemia in the G allele carrier's leukemia patients was also evident.

DOI

10.21608/jcbr.2020.25954.1014

Keywords

Adiponectin, Polymorphism, rs2241766, Leukemia, prognosis

Authors

First Name

Hewida

Last Name

Fadel

MiddleName

Hassan

Affiliation

Medical laboratory Technology, Allied Medical sciences, Pharos University in Alexandria

Email

hewida.fadel@pua.edu.eg

City

Alexandria

Orcid

0000-0002-6696-0405

First Name

Nahla

Last Name

Hefny

MiddleName

E

Affiliation

Department of Medical Laboratory Technology, Faculty of Allied Medical Science, Pharos University, Alexandria, Egypt

Email

-

City

-

Orcid

-

First Name

Amany

Last Name

Yousef

MiddleName

I

Affiliation

Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Nadia

Last Name

Sadek

MiddleName

A

Affiliation

Department of Hematology, Medical Research Institute, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Eman

Last Name

Attea

MiddleName

-

Affiliation

Department of Hematology, Faculty of Medicine, Alexandria University, Egypt

Email

-

City

Alexandria

Orcid

-

First Name

Tarek

Last Name

El-Sewedy

MiddleName

-

Affiliation

Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Egypt

Email

-

City

Alexandria

Orcid

-

Volume

4

Article Issue

1

Related Issue

10127

Issue Date

2020-04-01

Receive Date

2020-03-15

Publish Date

2020-04-01

Page Start

57

Page End

68

Print ISSN

2682-261X

Online ISSN

2682-2628

Link

https://jcbr.journals.ekb.eg/article_89038.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=89038

Order

8

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

The association of adiponectin polymorphism (rs2241766) with susceptibility and prognosis of Egyptian patients with hematological malignancies: A case-control study

Details

Type

Article

Created At

22 Jan 2023